Mining the CRBN target space redefines rules for molecular glue–induced neosubstrate recognition

待确认 20 由 leek 发布于 2026/6/17 15:48:47

DOI:10.1126/science.adt6736
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1126/science.adt6736

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Abstract：The CRL4CRBN E3 ubiquitin ligase is the target of molecular glue degrader compounds that reprogram ligase specificity to induce the degradation of clinically relevant neosubstrate proteins.

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