β-hydroxybutyrate enhances the metabolic fitness of CAR T cells in cancer

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DOI:10.1016/j.cell.2026.02.004
作者：Shan Liu, Puneeth Guruprasad, Ranjani Ramasubramanian, Bhoomi Madhu, Luca Paruzzo, Kecheng Han, Andre Kelly, Alexander Shestov, He N. Xu, Alberto Carturan, Chaoting Zhou, Kevin R. Amses, Amichay Afria
文献类型：期刊论文
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Elsevier

Abstract：The influence of lifestyle factors, such as diet, on the effectiveness of T cell-mediated cancer immunotherapies remains unclear. Here, we demonstrate that the ketogenic diet (KD)-induced ke

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