Development of an engineered ketoreductase with improved activity, stereoselectivity and relieved substrate inhibition for enantioselective synthesis of a key (R)-α-lipoic acid precursor

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DOI:10.1016/j.mcat.2022.112208
作者：Chen Hu ,?Baijun Ye ,?Zedu Huang ,?Fener Chen
文献类型：期刊论文
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Elsevier

Abstract：Methyl (R)-8-chloro-6-hydroxyoctanoate ((R)-MCHO, (R)-2a) is a key precursor that can be utilized in the production of (R)-α-lipoic acid ((R)-LA) of pharmaceutical and dietary significance.

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