Discovery of a Hydroxamic Acid-Based HDAC11 Isoform-Selective Inhibitor with Oral Anti-AML Potency.

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DOI:10.1021/acs.jmedchem.5c03107
作者：Qipeng Chai,Maoshuo Yang,Chunxi Liu,Xiaolan Zhu,Lina Liu,Wei Zhao,Xintong Xue,Jinwei Zhang,Lanlan Liu,Wenjing Wang,Fabao Liu,Xiaona You,Yingjie Zhang
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Our previous study not only demonstrated that HDAC11 is a potential therapeutic target for AML but also discovered a specific HDAC11 inhibitor A9 as an anti-AML lead compound. The purpose of

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