T-cell receptor gene therapy targeting KRAS G12V for advanced pancreatic cancer in a single-arm phase 1/2 clinical trial.

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DOI:10.1016/j.ymthe.2026.03.012
作者：Xiongfei Xu,Haihui Gu,Zhanshan Cha,Bin Zhang,Shuai Yuan,Xiuwen Ding,Lei Gao,Suizhi Gao,Xinqian Wu,Lingyun Gu,Jianye Huang,Jianling Hao,Penghao Li,Yikai Li,Xiaochao Kang,Xiaohan Shi,Xiaoyi Yin,Huan Wan
文献类型：期刊论文
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Elsevier

Abstract：Adoptive T-cell transfer targeting KRAS G12D can induce tumor regression in advanced epithelial cancers. The safety, efficacy of TCR-T cells targeting KRAS G12V, and potential benefit of rep

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