Development and validation of an ultra-sensitive UPLC-MS/MS method for quantification of monomethyl auristatin E in cynomolgus monkey plasma: application to pharmacokinetic study.

已取消 10 由 honey 发布于 2026/3/20 10:09:38

DOI:10.1080/17576180.2026.2641573
作者：Bing Zhang, Lei Zhang, Yanfeng Liu, Weimin Hu, Rui Diao, Lili Xing, Yi Tao, Liang Shen
文献类型：期刊论文
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Taylor & Francis

Abstract：Introduction: Antibody-drug conjugates (ADCs) represent a cutting-edge approach in cancer therapy, with monomethyl auristatin E (MMAE) frequently used as a payload in ADC development. We hav

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