PSMD14-mediated PFKFB2 deubiquitination activates H3K27 lactylation to drive cancer stemness in gastric adenocarcinoma

已完结 10 由吕优优发布于 2026/3/21 19:31:02

DOI:10.1038/s41418-025-01605-5
作者：Xiaoya Zhao, Mengmeng Li, Yao Fu, Chen Chen, Yali Chen, Lei Xu, Linsen Bao, Zhuang Ma, Jiawen Xu, Shimeng Zhou, Yun Qian, Bo Wang, Qiang Wang, Jian He, Qingqing Ding, Meng Wang, Qilong Wang, Zhangding
文献类型：期刊论文
补充材料：只需要正文

Springer

Abstract：Deubiquitinases (DUBs) are pivotal in cancer progression, yet their role in metabolic reprogramming in gastric adenocarcinoma (GAC) remains unclear. Here, we discover that highly expressed P

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