Mechanistic Insight-Guided Protein-Engineering Strategies Lead to the Control of Cytochrome-P450-Mediated Regioselectivity of Midchain Fatty Acid C–H Activation

已取消 10 由 CZX 发布于 2026/3/23 19:34:13

DOI:10.1021/acscatal.5c09172
作者：Bethan S. Jones, Jordi Soler, Joseph W. Sharratt, Bethany N. Hogg, Michele Tavanti, Christian Schnepel, Nico Kress, Lisa S. Seibt, Sílvia Osuna, Marc Garcia-Borràs, Sabine L. Flitsch
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American Chemical Society (ACS)

Abstract：Regioselective midchain hydroxylation of fatty acids is an attractive chemical transformation, producing high-value hydroxy fatty acids and lactones. However, achieving such regioselective C

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