A logic-gated trispecific engager enhances macrophage killing of cancer cells in solid tumors.

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DOI:10.1038/s41587-026-03057-9
作者：Xiaotian Zhao,Weiqiang Jing,Ganyu Wang,Zhanyan Liu,Xinxin Xu,Maosen Han,Zhipeng Fu,Yulin Zhang,Zuolin Zheng,Jing Zhang,Longyu Bo,Xianghui Dong,Caiping Li,Yanhua Sun,Junfeng Zhang,Fabao Zhao,Nianzeng X
文献类型：期刊论文
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Nature

Abstract：The antitumor efficacy of immune cell engagers that bind two targets on the same immune cell is limited by structural constraints, leading to incomplete coengagement and uncoordinated signal

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