MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation

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DOI:10.1038/s41594-023-00988-8
作者：Tong Dai,?Lei Zhang,?Yu Ran,?Meirong Zhang,?Bing Yang,?Huasong Lu,?Shixian Lin,?Long Zhang,?Fangfang Zhou
文献类型：期刊论文
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Abstract：Mitochondrial antiviral signaling protein (MAVS) is an adapter that recruits and activates IRF3. However, the mechanisms underpinning the interplay between MAVS and IRF3 are largely unknown.

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