Discovery and Engineering Imine Reductase for Gram-Scale Synthesis of (S)-Nicotine.

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DOI:10.1021/acs.orglett.6c00459
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1021/acs.orglett.6c00459

American Chemical Society (ACS)

Abstract：An engineered imine reductase variant capable of synthesizing (S)-nicotine was developed through structure-guided directed evolution. Enzyme library screening identified IR-55 as an ideal pa

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