Structure–Activity Relationship Studies of an Autophagy Inhibitor That Targets the ATG14L-Beclin1 Protein–Protein Interaction Reveal Modifications That Improve Potency and Solubility and Maintain Selectivity

已完结 10 由 SDRD 发布于 2025/12/30 17:47:57

DOI:10.1021/acs.jmedchem.4c02312
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1021/acs.jmedchem.4c02312

American Chemical Society (ACS)

Abstract：Autophagy, a recycling process in eukaryotes, contributes to tumor growth and metastasis by alleviating cellular stress and facilitating survival and chemoresistance. The development of smal

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