Flower-Shaped Lipid Nanoparticles Evade Apolipoprotein E-Mediated Liver Tropism for Safe and Enhanced Cytokine-Based Cancer Immunotherapy

已完结 10 由柚子发布于 2025/12/29 17:41:24

DOI:10.1021/acsnano.5c11552
作者：Yiming Qi, , , Yuli Fu, , , Xueer Wu, , , Ziyan Chen, , , Yuepeng Tang, , , Hoitong Ao, , , Haichao Zhu, , , Chenming Zou, ,
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Lipid nanoparticles (LNPs) are effective carriers for intratumoral delivery of cytokine-encoding mRNA, but their clinical use is limited by apolipoprotein E (ApoE)-mediated hepatic tropism,

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