Design, synthesis, and biological evaluation of novel PROTACs based on unnatural dipeptide CRBN ligands

已完结 10 由 YIYA 发布于 2026/1/4 11:37:14

DOI:10.1016/j.ejmech.2025.118387
作者：Kun Huang , Peng Luo , Cai-Hua Li , Nan Huang , Kun Yao , Xiong-Xiong Lan , Ling-Feng Du , Yan Miao , Qing Tang , Ying Xu , Yong-Xia Zhu , Ning-Y
文献类型：期刊论文
补充材料：只需要正文

Elsevier

Abstract：Cereblon (CRBN), the target of immunomodulatory drugs (IMiDs) such as thalidomide and lenalidomide, serves as the substrate recognition subunit of the CRL4CRBN E3 ubiquitin ligase complex. T

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