Solid tumour CAR-T cells engineered with fusion proteins targeting PD-L1 for localized IL-12 delivery.

已完结 20 由 bobobo 发布于 2025/12/9 13:25:36

DOI:10.1038/s41551-025-01509-2
作者：John P Murad,?Lea Christian,?Reginaldo Rosa,?Yuwei Ren,?Alyssa J Buckley,?Eric Hee Jun Lee,?Lupita S Lopez,?Anthony K Park,?Jason Yang,?Yukiko Yamaguchi,?Candi Trac,?Lauren N Adkins,?Wen-Chung Chang,?
文献类型：期刊论文
补充材料：仅需补充材料

Nature

Abstract：Chimeric antigen receptor (CAR)-T cell efficacy in solid tumours is limited due in part to the immunosuppressive tumour microenvironment (TME). To improve antitumour responses, we hypothesiz

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