A first-in-class EGFR-directed KRAS G12V selective inhibitor

已完结 10 由 RNA痴发布于 2025/12/12 11:11:01

DOI:10.1016/j.ccell.2025.05.016
作者：Lyla J. Stanland, Hayden P. Huggins, Snehasudha S. Sahoo, Alessandro Porrello, Yogitha Chareddy, Salma H. Azam, Jillian L. Perry, Pradeep S. Pallan, Kristina Whately, Lincy Edatt, William D. Green, Ma
文献类型：期刊论文
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Elsevier

Abstract：Despite KRASG12V being the second most common KRAS mutation in cancer, no direct inhibitors targeting KRASG12V have been approved. RNA interference (RNAi) has faced numerous obstacles as can

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