Discovery of Potent, Highly Selective, and Efficacious SMARCA2 Degraders

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DOI:10.1021/acs.jmedchem.4c01878
作者：Zhenwu Li, Lalgudi S. Harikrishnan, Guozhang Xu, Debangshu Samanta, Jose C. Clemente, Lingying Leng, Wenbin Tu, Lin Yang, Liyue Huang, Mi Wang, Shaomeng Wang, Qiaolin Deng, Elham Behshad, Rakesh Nagil
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：We describe the identification of selective SMARCA2, VHL-based heterobifunctional degraders. Structurally novel indolo[1,2-a]quinazolin-5(7H)-one SMARCA bromodomain binders were optimized an

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