Design and Development of a Novel Oral 4′-Fluorouridine Double Prodrug VV261 against SFTSV

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DOI:10.1021/acs.jmedchem.5c00626
作者：Yong Cheng, Wei Zheng, Xinru Dong, Tengxiao Sun, Mengwei Xu, Li Xiang, Jian Li, Huilong Wang, Xiaoqin Jian, Jingjin Yu, Pengcheng Li, Tianwen Hu, Guanghui Tian, Xiangrui Jiang, Leike Zhang, Haji A. Ai
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：4′-Fluorouridine (4′-FU), despite demonstrating potent anti-SFTSV efficacy in vitro and in vivo, faces hindrances in its further development as a promising drug due to its weak chemical stab

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