Therapy-induced rapid drug resistance driven by genome chaos and polyploid giant cancer cells

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DOI:10.1016/j.canlet.2026.218355
作者：Steven D. Horne ,?Jing Christine Ye ,?Guo Liu ,?Batoul Y. Abdallah ,?Joshua B. Stevens ,?Henry H. Heng
文献类型：期刊论文
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Elsevier

Abstract：Initially effective cancer drug treatments often lead to resistance with greater aggressiveness. Traditionally, this is attributed to preexisting mutation/epigenetic heterogeneity, which all

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