Efficacious Combination Drug Treatment for Colorectal Cancer That Overcomes Resistance to KRAS G12C Inhibitors.

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DOI:10.1158/1535-7163.MCT-22-0411
作者：Hiroyuki Matsubara,?Hiroyuki Miyoshi,?Fumihiko Kakizaki,?Tomonori Morimoto,?Kenji Kawada,?Takehito Yamamoto,?Kazutaka Obama,?Yoshiharu Sakai,?Makoto Mark Taketo
文献类型：期刊论文
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American Association for Cancer Research (AACR)

Abstract：Recent advances in combinatorial chemistry led to the discovery of inhibitors targeting the KRAS G12C-mutant protein. However, efficacy of its monotherapy on colorectal cancer is limited. Th

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