Developing analytical ion exchange chromatography methods for antibody drug conjugates containing the hydrolysis-prone succinimide-thioether conjugation chemistry

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DOI:10.1016/j.xphs.2024.08.021
作者：Jessica Webb,?Chendi Niu,?Benjamin Ritter,?Methal Albarghouthi,?Xiaoyu Chen,?Chunlei Wang
文献类型：期刊论文
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Elsevier

Abstract：Charge variants are one of the most important quality attributes for protein therapeutics, including antibody drug conjugates (ADCs). ADCs are conjugation products between monoclonal antibod

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