Anti-FAP CAR T cells produced in vivo reduce fibrosis and restore liver homeostasis in metabolic dysfunction–associated steatohepatitis

已完结 10 由 SWIFT 发布于 2026/1/26 8:10:19

DOI:10.1126/scitranslmed.adx0368
作者：Chittampalli N. Yashaswini,?Bruno Cogliati,?Tianyue Qin,?Tran To,?Thomas Williamson,?Tyler E. Papp,?Kenneth Li,?Raisa Rasul,?Li Chen,?Adi Lightstone,?Haig Aghajanian,?Hamideh Parhiz,?Shuang Wang,?Joel
文献类型：期刊论文
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American Association for the Advancement of Science (AAAS)

Abstract：Hepatic fibrosis is a key predictor of mortality in liver disease, driven by fibrogenic hepatic stellate cells (HSCs). Targeting these fibrogenic cells may therefore offer a therapeutic appr

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