Lactylation of XLF promotes non-homologous end-joining repair and chemoresistance in cancer

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DOI:10.1016/j.molcel.2025.06.019
作者：Mingpeng Jin, Bingsong Huang, Xiaoning Yang, Shuyang Wang, Jinhuan Wu, Yiming He, Xin Ding, Xuanhe Wang, Zhe Wang, Jie Yang, Rui Li, Xuan Zhou, Qianwen Wang, Yunhui Li, Lei Li, Wen Zheng, Zhikai Zeng,
文献类型：期刊论文
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Elsevier

Abstract：Metabolic reprogramming and DNA damage repair are essential in tumorigenesis and chemoresistance, yet their link remains elusive. Here, we show that LDHA deficiency impairs NHEJ and class sw

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