In Vivo mRNA CAR T Cell Engineering via Targeted Ionizable Lipid Nanoparticles with Extrahepatic Tropism

待确认 10 由 Faye 发布于 2026/1/24 14:11:43

DOI:10.1002/smll.202304378
作者：Margaret M. Billingsley,&nbsp;Ningqiang Gong,&nbsp;Alvin J. Mukalel,&nbsp;Ajay S. Thatte,&nbsp;Rakan El-Mayta,&nbsp;Savan K. Patel,&nbsp;Ann E. Metzloff,&nbsp;Kelsey L. Swi
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Wiley

Abstract：With six therapies approved by the Food and Drug Association, chimeric antigen receptor (CAR) T cells have reshaped cancer immunotherapy. However, these therapies rely on ex vivo viral trans

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