Design and evaluation of novel pyrimidine-based nucleoside analogs as antivirals: Identification of MCH-1623 as a potent broad-Spectrum antiviral candidate

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DOI:10.1016/j.bioorg.2026.109472
作者：Xu Yan , Hao Sun , Chunhuan Mo , Ling Ma , Chunbin Hu , Zhenyu Zhong , Yi Su , Lehua Yin , Jinyan Zhang , Jia Chen , Yaohui Liu , Xia Han , 
文献类型：期刊论文
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Elsevier

Abstract：Expanding the chemical diversity of nucleosides is a vital challenge in developing antivirals. It is suggested that their volume restricts viral RdRP recognition of bases. Since the volume o

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