A cereblon-based glue degrader of NEK7 regulates NLRP3 inflammasome in a context-dependent manner

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DOI:10.1016/j.chembiol.2025.06.005
作者：Aude Sylvain ,?Natacha Stoehr ,?Fupeng Ma ,?Artiom Cernijenko ,?Martin Schr?der ,?Maryam Khoshouei ,?Melanie Vogelsanger ,?Michel Schoenboerner ,?Ashley Burke ,?Pasupuleti Rao ,?Jonathan M. Solomon ,?
文献类型：期刊论文
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Elsevier

Abstract：Aberrant NLRP3 (NACHT-, leucine-rich repeat [LRR]- and pyrin domain [PYD]- containing protein 3) inflammasome activation is linked to many inflammatory diseases, driving the search for thera

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