Antigen-specific profiling identifies T-bet⁺ melanoma-specific CD8⁺ T cells associated with response to neoadjuvant PD-1 blockade.

已完结 10 由团团发布于 2026/1/28 20:38:20

DOI:10.1016/j.ccell.2025.12.004
作者：Guanning Wang,?Daniel Yoon,?Ajeya Nandi,?Khushboo Patel,?Tarek Azar,?Justin Kim,?Nicholas A Han,?Aaron Nickie,?Stella Park,?Kevin Wang,?Patrick Yan,?Shraya Divaker,?Jennifer Tabita-Martinez,?Lydia Gil
文献类型：期刊论文
补充材料：只需要正文

Elsevier

Abstract：Despite widespread immune profiling in cancer immunotherapy, the antigen-specific responses that drive clinical outcomes remain poorly defined. In a prospective neoadjuvant trial (NCT0401385

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Antigen-specific profiling identifies T-bet+ melanoma-specific CD8+ T cells associated with response to neoadjuvant PD-1 blockade.

Antigen-specific profiling identifies T-bet⁺ melanoma-specific CD8⁺ T cells associated with response to neoadjuvant PD-1 blockade.