Conditional requirement for dimerization of the membrane-binding module for BTK signaling in lymphocyte cell lines

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DOI:10.1126/scisignal.ado1252
作者：Timothy J. Eisen,?Sam Ghaffari-Kashani,?Chien-Lun Hung,?Jay T. Groves,?Arthur Weiss,?John Kuriyan
文献类型：期刊论文
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American Association for the Advancement of Science (AAAS)

Abstract：Bruton’s tyrosine kinase (BTK) is a major drug target in immune cells. The membrane-binding pleckstrin homology and tec homology (PH-TH) domains of BTK are required for signaling. Dimerizati

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