Revealing the Role of the Arg and Lys in Shifting Paradigm from BTK Selective Inhibition to the BTK/HCK Dual Inhibition - Delving into the Inhibitory Activity of KIN-8194 against BTK, and HCK in the Treatment of Mutated BTK^Cys481 Waldenstr?m Macroglobulinemia: A Computational Approach.

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DOI:10.2174/1871520623666230208102609
作者：Ghazi Elamin,?Aimen Aljoundi,?Mohamed I Alahmdi,?Nader E Abo-Dya,?Mahmoud E S Soliman
文献类型：期刊论文
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Bentham Science

Abstract：Background: Despite the early success of Bruton's tyrosine kinase (BTK) inhibitors in the treatment of Waldenström macroglobulinemia (WM), these single-target drug therapies have limitations

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Revealing the Role of the Arg and Lys in Shifting Paradigm from BTK Selective Inhibition to the BTK/HCK Dual Inhibition - Delving into the Inhibitory Activity of KIN-8194 against BTK, and HCK in the Treatment of Mutated BTKCys481 Waldenstr?m Macroglobulinemia: A Computational Approach.

Revealing the Role of the Arg and Lys in Shifting Paradigm from BTK Selective Inhibition to the BTK/HCK Dual Inhibition - Delving into the Inhibitory Activity of KIN-8194 against BTK, and HCK in the Treatment of Mutated BTK^Cys481 Waldenstr?m Macroglobulinemia: A Computational Approach.