Evolution of the Synthesis Route for CC-99677: From Discovery toward Commercialization

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DOI:10.1021/acs.oprd.5c00278
作者：Alexander L. Ruchelman*, , , John R. Coombs, , , Antonio C. Ferretti, , , Adam J. Freitag, , , Peter Galebach, , , Maryll E. Geherty, , , Ji
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American Chemical Society (ACS)

Abstract：CC-99677 is an irreversible inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase 2 (MK2) that sustainably reduces production of proinflammatory cytokines in vitro. T

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