CARM1-mediated hypoxanthine-enriched exosomes rewire inosine metabolism and impair CD8+ T cell antitumor function

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DOI:10.1038/s41418-026-01673-1
作者：Jilong Yin, Zhipeng Su, Xi Hu, Haojie Sun, Zenghui Sun, Shuyu Zhou, Wenwen Xu, Ying Xi, Lanlan Liu, Jinwei Zhang, Qian Zhao, Yi Qiao, Jian Zhang, Yingjie Zhang, Ying Xu, Yuchen Fan, Xiaona You, Xiangb
文献类型：期刊论文
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Springer

Abstract：Cancer cells utilize tumor-derived exosomes to suppress antitumor immunity. Herein, we identify co-activator-associated arginine methyltransferase 1 (CARM1) as a key regulator of exosome bio

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