Discovery of Novel Natural Product-Based PDE4 Inhibitors for Ischemic Stroke Treatment without Emetogenicity at Ultra-High Doses.

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DOI:10.1021/acs.jmedchem.5c02951
作者：Chuang Xia,Mingjia Yu,Yujie Ni,Shanfang Fang,Kaiwen Feng,Tingting Zhang,Chunping Gu,Kaibin Huang,Zhong-Zhen Zhou
文献类型：期刊论文
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Abstract：Phosphodiesterase-4 (PDE4) inhibitors show potential for treating ischemic stroke, but are often constrained by emesis or low blood-brain barrier (BBB) permeability. To overcome these challe

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