Discovery of Novel Potent and Fast BTK PROTACs for the Treatment of Osteoclasts-Related Inflammatory Diseases

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DOI:10.1021/acs.jmedchem.3c01414
作者：Junli Huang, Zeli Ma, Xiaopeng Peng, Zichao Yang, Yuhao Wu, Guanghong Zhong, Tianfeng Ouyang, Zhen Chen, Yao Liu, Qirui Wang, Jianjun Chen*, Ting
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Bruton’s tyrosine kinase (BTK) is an attractive target in inflammatory and autoimmune diseases. However, the effectiveness of BTK inhibitors is limited by side effects and drug resistance. I

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