Design of optimized epigenetic regulators for durable gene silencing with application to PCSK9 in nonhuman primates.

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DOI:10.1038/s41587-025-02838-y
作者：Shaoshuai Mao,Wenbo Peng,Zhengyan Feng,Yang Chen,Jing Sun,Haiting Chen,Pengcheng Wang,Pinzheng Huang,Junzheng Zhao,Leilei Wu,Yifan Wang,Junjian Liu,Hao Luo,Ying Zang,Changqing Yang,Xue Qiao,Zhiwei Lu,
文献类型：期刊论文
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Nature

Abstract：Epigenetic editing is a promising strategy for modifying gene expression while avoiding the permanent alterations and potential genotoxicity of genome-editing technologies. Here we designed

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