Application of Bioisosteres in the Design and Discovery of FDA-Approved Drugs and Advanced Clinical Candidates.

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DOI:10.1021/acs.jmedchem.5c03492
文献类型：期刊论文
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文献链接：https://doi.org/10.1021/acs.jmedchem.5c03492

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Abstract：Since its introduction in 1951, bioisosterism has become a cornerstone strategy in drug design and development, enabling chemists to rationally modify molecular structures to optimize biolog

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