Discovery of PF-07054894, a Potent Squaramide-Based CCR6 Antagonist Displaying High CXCR2 Selectivity

已完结 10 由晴天发布于 2026/1/19 14:35:35

DOI:10.1021/acs.jmedchem.5c01946
作者：Mark E. Schnute*,?, ,?Huixian Wu,?, ,?John I. Trujillo,?, ,?Wei Li,?, ,?David Jonathan Wasilko,?, ,?Jennifer Alley,?, ,?Eric P. Arnold,?, ,?Scott W. Bagley,?, ,?Gabriel Berstein,?, ,?David C. Blakemor
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：The G protein-coupled receptor (GPCR) CCR6 mediates the migration of pathogenic immune cells to the site of inflammation in response to the chemokine CCL20. CCR6 is an attractive target for

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