STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor.

已完结 10 由橘子不是唯一的水果发布于 2025/10/24 9:31:17

DOI:10.1038/s41590-025-02283-8
作者：Bao-Cun Zhang,Alice Pedersen,Line S Reinert,Ying Li,Ryo Narita,Manja Idorn,Lili Hu,Morten K Skouboe,Sirui Li,Muyesier Maimaitili,Xiangning Ding,Yingying Cong,Jian Zhao,Marie-Louise Frémond,Kasper Mik
文献类型：期刊论文
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Nature

Abstract：NF-κB is central for activation of immune responses. Cytosolic DNA activates the cGAS–STING pathway to induce type I interferons (IFNs) and signaling through NF-κB, thus instigating host def

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