Rational design of VHL-recruiting KRASG12C proteolysis-targeting chimeras based on molecular dynamics simulation

已完结 10 由小小发布于 2025/11/3 17:40:16

DOI:10.1016/j.cclet.2025.110992
文献类型：期刊论文
补充材料：只需要正文

Elsevier

Abstract：The von Hippel-Lindau tumor suppressor (VHL) has been extensively used to develop degraders targeting numerous proteins of interest. However, studies on the rational design of VHL-proteolysi

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