Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα

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DOI:10.1021/acs.jmedchem.2c01422
作者：Emily J. Hanan*,?Marie-Gabrielle Braun,?Robert A. Heald,?Calum MacLeod,?Connie Chan,?Saundra Clausen,?Kyle A. Edgar,?Charles Eigenbrot,?Richard Elliott,?Nicholas Endres,?Lori S. Friedman,?Emily Gogol,
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Small molecule inhibitors that target the phosphatidylinositol 3-kinase (PI3K) signaling pathway have received significant interest for the treatment of cancers. The class I isoform PI3Kα is

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