Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement.

已完结 10 由饼干发布于 2025/11/4 19:07:03

DOI:10.1021/acs.jmedchem.5c02412
作者：Juraj Velcicky,Jean-Baptiste Langlois,Michael Wright,Philipp Janser,Daniela Angst,Christelle Arnold,Karen Beltz,Silke Brenneisen,Celine Dubois,Janet Dawson,Christian Fischer,Nina Gommermann,Andreas He
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1021/acs.jmedchem.5c02412

American Chemical Society (ACS)

Abstract：NLRP3 is a molecular sensor present in innate immune cells which recognizes a variety of danger signals such as MSU, ATP, or Aβ. Upon activation, it seeds a protein complex termed the inflam

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