Evolution and co-occurrence of PI3K pathway gene mutations in endometrial carcinoma molecular subtypes at the single-cell level

已完结 20 由青柠qn 发布于 2025/11/7 14:40:08

DOI:10.1158/1078-0432.ccr-25-1237
作者：Arnaud Da Cruz Paula, Yingjie Zhu, David N. Brown, Shirin Issa Bhaloo, Fresia Pareja, Timothy J. Hoang, Hunter Green, Thais Basili, Higinio Dopeso, Pier Selenica, Edaise M. da Silva, Nadeem Riaz, Sara
文献类型：期刊论文
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American Association for Cancer Research (AACR)

Abstract：Purpose: The PI3K pathway is altered in gt;85% of endometrioid endometrial carcinomas (EECs), with multiple mutations commonly co-occurring. Yet, the therapeutic effects of single-agent PI3K

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