Engineering CAR T cells to secrete VEGF-neutralizing scFvs enhances antitumor activity against solid tumors

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DOI:10.1126/scitranslmed.adw9286
作者：Torahito A. Gao, Ryan M. Shih, Justin D. Clubb, Shao-Hsi Hung, Tanya Singh, Laura B. James-Allan, Gabriella DiBernardo, Amanda Shafer, Amber Bouren, Melani
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American Association for the Advancement of Science (AAAS)

Abstract：Chimeric antigen receptor (CAR) T cell therapy has shown limited efficacy against solid tumors, which often reside in highly immunosuppressive tumor microenvironments (TMEs). TMEs can be hig

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