Targeted clearance of extracellular Tau using aptamer-armed monocytes alleviates neuroinflammation in mice with Alzheimer's disease.

已完结 10 由 aaa 发布于 2025/10/19 10:58:13

DOI:10.1038/s41551-025-01525-2
作者：Yuting Zhuo,Yao Lu,Yan Zhu,Nachuan Wen,Guangjing Zou,Hongkun Lu,Xinyu Pei,Yutong Zhang,Qiang Zhang,Xin Wang,Wenjuan Zhang,Qingyang Zhang,Zhimin Wang,Sitao Xie,Chang-Qi Li,Weihong Tan,Liping Qiu
文献类型：期刊论文
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Nature

Abstract：Extracellular Tau determines the progression of Alzheimer's disease, yet therapeutic strategies targeting it are hindered by poor brain delivery and limited clearance. Here we developed a Ta

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