Strategies to address low drug solubility in discovery and development.

已完结 10 由 wuwu 发布于 2025/11/24 11:06:46

DOI:10.1124/pr.112.005660
作者：Hywel D Williams,?Natalie L Trevaskis,?Susan A Charman,?Ravi M Shanker,?William N Charman,?Colin W Pouton,?Christopher J H Porter
文献类型：期刊论文
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Elsevier

Abstract：Drugs with low water solubility are predisposed to low and variable oral bioavailability and, therefore, to variability in clinical response. Despite significant efforts to "design in" accep

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