Process Development of the BACE Inhibitors BI 1147560 BS and BI 1181181 MZ

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DOI:10.1021/acs.oprd.2c00325
作者：Guisheng Li,?Zhulin Tan,?Yibo Xu,?Kanwar P. S. Sidhu,?Bo Qu,?Melissa A. Herbage,?Magnus C. Eriksson,?Xingzhong Zeng,?Carl A. Busacca,?Jean-Nicolas Desrosiers,?Thomas Hampel,?Oliver Niemeier,?Carsten R
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：The development of large-scale syntheses of two beta-site amyloid precursor protein cleaving enzyme (BACE) inhibitors is described. New methodologies were discovered to overcome safety and s

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