GPNMB-directed CAR T cell therapy against MiT/TFE-family fusion-driven solid tumors.

求助中 10 由 Faye 发布于 2026/7/28 9:04:48

DOI:10.1038/s43018-026-01194-3
作者：Franz J Zemp, Zackariah Breckenridge, Hyojin Song, Gurveer S Gill, Taye L Louie, Kiran Narta, Hongrui Liu, Yeon Suh, Louisa Guignard, Edna Ayerim Mandujano
文献类型：期刊论文
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Nature

Abstract：Chimeric antigen receptor (CAR) T cell therapy for solid tumors is constrained by the scarcity of safe, uniformly expressed cell-surface targets. Here we identify glycoprotein NMB (GPNMB)-an

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