Discovery of Potent and Selective Pyrrolo[2,3-d]Pyrimidine-Based Aurora A Inhibitors with Demonstrated Efficacy against Patient-Derived Gastric Cancer Organoids

已完结 10 由 SDRD 发布于 2025/12/2 12:38:59

DOI:10.1021/acs.jmedchem.5c01886
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1021/acs.jmedchem.5c01886

American Chemical Society (ACS)

Abstract：Aurora A kinase, a key regulator of mitosis, has emerged as a promising therapeutic target for gastric cancer. However, challenges related to selectivity and resistance highlight the urgent

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