Pharmaceutical Nitrosamines: A Comprehensive Review of Health Risks, Detection, Mitigation Strategies Supplemented with CYP450 Interactions as Molecular Simulations for Mechanistic Insight into Carcinogenicity

已完结 10 由 YAN 发布于 2025/12/2 10:33:33

DOI:10.1021/acs.molpharmaceut.4c01173
作者：Kardile Punam Kashinath,?Md Samim Sardar,?Subhadeep Roy,?Anoop Kumar* and Santanu Kaity*,?
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Nitrosamines, identified as unexpected impurities in several drug substances and drug products, have raised significant concern due to their mutagenic and carcinogenic properties. Extensive

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