Design, chemical synthesis, and in vitro biological evaluation of simplified estradiol–adenosine hybrids as inhibitors of 17β-hydroxysteroid dehydrogenase type 1

已完结 40 由小小发布于 2025/11/10 16:46:28

DOI:10.1139/V09-083
作者：Marie Bérubé,?D. Poirier
文献类型：期刊论文
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Abstract：A series of estradiol (E2) derivatives were designed to interact with both the substrate- and the cofactor-binding sites of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1). These analogue

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