MLH1 Mismatch Repair Deficiency Predicts Exceptional Response to Immune Checkpoint Inhibition in Clear-cell Renal Cell Carcinoma

已完结 10 由 123 发布于 2025/11/14 8:20:59

DOI:10.1016/j.eururo.2025.09.4162
作者：Mark T. Dawidek, Lina Posada Calderon, Parantu K. Shah, Rohan Mittal, Burcin Agridag Ucpinar, Ziad Bakouny, Kevin Meli, Eddy Saad, Renée-Maria Saliby, H. Jun Woo, Yash S. Khandwala, Marc Eid, Chris L
文献类型：期刊论文
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Elsevier

Abstract：Immune checkpoint inhibition can result in deep and durable responses in clear-cell renal cell carcinoma (ccRCC), yet no biomarkers currently guide management. While mismatch repair (MMR) de

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